Post‐translational modifications regulate each step of DNA replication to ensure the faithful transmission of genetic information. In this context, we recently showed that deubiquitination of SUMO2/3 and SUMOylated proteins by USP7 helps to create a SUMO‐rich and ubiquitin‐low environment around replisomes that is necessary to maintain the activity of replication forks and for new origin firing. We propose that a two‐flag system mediates the collective concentration of factors at sites of DNA replication, whereby SUMO and Ubiquitinated‐SUMO would constitute “stay” or (...) “go” signals respectively for replisome and accessory factors. We here discuss the findings that led to this model, which have implications for the potential use of USP7 inhibitors as anticancer agents. (shrink)

The axiom Extra Ecclesiam nulla salus was drawn up by Cyprian of Carthage in the middle of the third century. In the Middle Ages it was essential for the pontifical theocracy with popes like Gregory VII (Dictatus papae, 1075) Inocent III (IV Lateran Council, 1215) and Boniface VIII (Bull Unam Sanctam , 1302).With the necessary adaptations and nuances (St. ThomasAquinas in the XIIIth century; the theologians of Salamanca in the XVIth century, the II Vatican Council in the XXth century) the (...) controversy around this maxim has reached our days. (shrink)

A lo largo de la Edad Media se fijó en siete el número de sacramentos. Dos de ellos serán reconocidos como «sociales» por establecer las formas e ideales de vida de dos categorías humanas. A una minoría reconocida como guía moral –el orden sacerdotal– se le pide un compromiso con el celibato. A la masa de fieles –el laicado– se le proponía el estado conyugal según normas –las del matrimonio cristiano– que le distinguían de otras formas de relación carnal. En (...) ambos casos, sin embargo, lo real y lo ideal frecuentemente difieren. (shrink)

Las polémicas entre mentira (importante vitium linguae según los moralistas) y verdad (identificada con una idea superior, incluso con la divinidad) han sido muy características de la Europa cristiana medieval. Sobre bases bíblicas, patrísticas, escolásticas y prerrenacentistas, las disputas han afectado tanto a los medios académicos (vg. la teoría de la Duplex veritas atribuida a los averroístas) como al común de los cristianos (vg. El recurso a la ordalía).

AimThe functional prognosis of patients after coma following either cardiac arrest or acute structural brain injury is often uncertain. These patients are associated with high mortality and disability. N20 and N70 somatosensory evoked potentials are used to predict prognosis. We evaluated the utility of SSEP as an early indicator of long-term prognosis in these patients.MethodsThis was a retrospective cohort study of patients admitted to the intensive care unit with a diagnosis of coma after CA or ABI. An SSEP study was (...) performed, including N20 and N70 at 24–72 h, after coma onset. Functional recovery was assessed 6–12 months later using the modified Glasgow scale. The study was approved by our local research ethics committee.ResultsIn the CA and ABI groups, the absence of N20 or N70 was a strong indicator of poor outcome. Conversely, the presence of N70 was an indicator of a good outcome.ConclusionSomatosensory evoked potentials are useful early prognostic markers with high specificity and sensitivity. Moreover, N70 has additional potential value for improving the prediction of good long-term functional outcomes.Clinical Trial Registration:[https://clinicaltrials.gov/], identifier [2018/01/001]. (shrink)

Resumen: En la historia de la recepción de Samuel Beckett en los países de habla no inglesa, la primera traducción de Comment c’est al castellano, realizada por José Emilio Pacheco en 1966, aparece como un hito aislado y deslumbrante. Esta traducción a partir del texto original en francés, hecha por el poeta mexicano cuando tenía 27 años, no tuvo una repercusión notable en su momento, a pesar de la audacia de la empresa y de la brillantez de la traducción. (...) Sin embargo, a raíz de la trayectoria de Pacheco como crítico, traductor y poeta de primera magnitud, se considera necesario hacer una evaluación en profundidad de este texto único. El objetivo de este artículo es el de analizar la versión de Pacheco del texto beckettiano por medio de un acercamiento al contexto histórico y a los elementos propios de su bagaje cultural que el poeta aporta a la elaboración de su traducción. Se trata, en definitiva, de explicar cómo se lee a Beckett en español por medio de Pacheco.: The first translation into Spanish of Samuel Beckett’s Comment c’est, by José Emilio Pacheco, Cómo es, stands out as a dazzling and unprecedented landmark in the history of the reception of the Irish author in non-English-speaking countries. In his translation the 27-year-old Mexican poet took the French original version as his main source but, despite its daring quality and the brilliance of the text rendered into Spanish, it had little impact in the cultural atmosphere of its day. In light of Pacheco’s standing in the world of letters as a first-rank critic, translator and poet, it is deemed necessary a reassessment of this unique text. The aim of this article is to analyze Pacheco’s translation of Samuel Beckett’s novel; for this purpose, the historical context and the personal elements that the poet incorporated from his personal background into his version of Comment c’est will be studied in detail. All in all, the final objective of this research is to explain how Beckett is read in Spanish through Pacheco’s version. (shrink)

La introducción al ensayo relaciona la escritura y la supervivencia en Unamuno y en Lledó -en el primero como voluntad multidimensional y en el segundo como memoria viva colectiva- y después compendia la vida y la obra de Emilio Lledó El ensayo comenta varios textos de la obra de Lledó Memoria de la ética acerca de la muerte y de la existencia extendida en la época clásica de la cultura y la filosofía griegas. Como conclusión, y a partir del (...) epicureísmo de Lledó, se reafirma una cierta distinción entre las propuestas de una teoría de la vida post-mortem basada en la pervivencia por la memoria y otra que apunta a la vida perdurable por el impulso del ánimo o thymós. (shrink)

Rationale, aims and objectives Given the increasing prevalence of cataract and demand for cataract extraction surgery, patients must often wait to undergo this procedure. We validated a previously developed priority scoring system in terms of clinical variables, pre-intervention health status, appropriateness of surgery and gain in visual acuity (VA) and health-related quality of life (HRQoL).Methods Explicit prioritization criteria for cataract extraction created by a variation of the Research and Development (RAND) and University of California Los Angeles appropriateness methodology were retrospectively (...) applied to a prospective cohort of 5257 patients on waiting lists to undergo cataract by phacoemulsification at 17 hospitals in Spain. Demographic data, clinical data and data related to surgical technique were collected by trained ophthalmologists. Patients were evaluated by their ophthalmologist before the intervention and 6 weeks afterward. They also completed, by mail, the Visual Function Index (VF-14) before the intervention and 3 months afterward.Results High-priority patients experienced greater improvement in VA and HRQoL than those classified as intermediate or low-priority (P < 0.0001), even after adjusting by VA and the VF-14 score at baseline. The time to intervention was the same for high-priority patients as it was for intermediate and low-priority patients.Conclusions The priority score we developed identified patients most likely to experience the greatest improvements from cataract extraction. Use of this tool could provide a fairer and more rational way to prioritize patients for cataract extraction. (shrink)

[español] En primer lugar, el texto ofrece un acercamiento al papel que amor y nostalgia cumplen en la poesía de Emilio Prados, así como a su íntimo nexo con la muerte como aniquilación mística. Como herramienta interpetativa, recurriré a la razón poética de María Zambrano, autora profundamente emparentada, vital y teóricamente, con la poesía pradiana. Este enfoque permitirá una visión de conjunto sobre la obra del poeta español y en segundo lugar, trazar una comparativa con el saudosismo de Teixeira (...) de Pascoaes. Así, indicaré las numerosas coincidencias que existen entre ambos y me detendré en la cuestión de la muerte mística, ámbito más problemático, donde sin embargo, puede apreciarse una comunión de espíritu entre el español y el portugués. ****************** [english] Firstly, the text offers an approach to the function of love and nostalgia in the poetry of Emilio Prados, as much as its intimate connection with death as mystical annihilation. As interpretive tool, I will use the poetic reason of María Zambrano, an author deeply linked, vital and theoretically, with pradian poetry. This focus will provide an overall view of Prado's work and the possibility of a comparison with Teixeira de Pascoaes's saudosism. Thus, I will point same coincidences between them and I will consider the question of mystical death. This sphere, although it is problematic, can show some kind of community of spirit between both. (shrink)

El que en el presente libro se confronten "lenguaje" e "historia" pretende indicar que una parte especial de los que hemos sido se hace presente como "lenguaje"; pero, además, según se analiza en sus páginas, la función del historiador tuvo, en principio, algo elemental y simple. La misma etimología de la palabra significa alguien a quien se le pide consejo sobre un hecho porque "él vio lo que pasó". Al decir lo que ve, lo que interpreta, el historiador compromete la (...) veracidad de su propio ser. Colección Clásicos - Dykinson (títulos publicados)?Serie estudios?? - Sobre la democracia ateniense. Luis Gil Fernández. - Derecho natural y dignidad humana. Ernst Bloch. - Alejo Carpentier. Poética del Mediterráneo Caribe. Inmaculada López Calahorro. - P. Szondi. Teoría del drama moderno. Ensayo sobre lo trágico. - El concepto poíesis en la filosofía griega. Emilio Lledó. - Lenguaje e historia. Emilio Lledó.?Serie textos? - Heródoto. Historia. Libro I. Ed. bilingüe de J. M. Floristán. - Sófocles. Electra. Ed. bilingüe de Luis Gil Fernández. - Platón. Fedro. Ed. bilingüe de Luis Gil Fernández. - Aristóteles. Poética. Ed. bilingüe de Paloma Ortiz García. - Horacio. Arte poética. Ed. bilingüe de Luis Gil Fernández. - Boileau. El arte poética y otras sátiras. Ed. bilingüe de Alberto Torrego Salcedo. - Lezama Lima. Escritos de Estética. Ed. de Pedro Aullón de Haro. - República poética. Textos programáticos de la literatura española (siglos XVIII y XIX). Ed. de Germán Garrido Miñambres. (shrink)

Introduction to the World Government /World Governance symposium.

En sus primeras lecciones de Friburgo, Heidegger planteó que una conceptuación originariamente filosófica debía tener un carácter indicativo-formal. Esto involucraba una transformación metodológica de la fenomenología hacia una hermenéutica de la vida fáctica. En este artículo se expone cómo la asunción de un procedimiento indicativo-formal permite a Heidegger superar ciertos problemas, apuntados por Natorp, que amenazaban la comprensión de Husserl de la fenomenología. Por otra parte, se hace también una consideración crítica del planteamiento fenomenológico original de Heidegger. In his first (...) Freiburg lessons Heidegger proposed that an original philosophical conceptualization had to have a formal-indicative character. This involved a deep methodological transformation of phenomenology towards a hermeneutics of factual life. This work expounds how the assumption of a formal-indicative procedure allows Heidegger to overcome certain problems of Husserl's understanding of phenomenology, which Natorp had pointed out. Besides, this paper makes a critical consideration of Heidegger's original phenomenological approach. (shrink)

Es, quiza, la coleccion mas abierta que existe en cuestiones de etica, aunque se ha ocupado tambien de antropologia, estetica, ontologia, teoria del conocimiento e historia de la filosofia. El primer titulo que se publico en la coleccion fue la gran Historia de la filosofia y de la ciencia en tres volumenes de Ludovico Geymonat. A este le han seguido obras de A. J. Ayer, A. MacIntyre, Ernst Tugendhat, Antoni Domenech, Anna Estany, Agnes Heller, F. Fernandez Buey, Carlos Paris, (...) class='Hi'>Emilio Lledo, Manuel Sacristan, John Rawls o Ludwig Wittgenstein. Victoria Camps ha dirigido, ademas, una gran Historia de la etica, en tres volumenes, en la que han colaborado los mejores especialistas espanoles. (shrink)

According to the broaden-and-build theory of positive emotions, the frequency of positive emotions is associated with the development of positive attitudes, cognitions, and behaviors in organizational contexts. However, positive and negative attitudes at work might also be influenced by different personal and job resources. While emotional intelligence has been significantly associated with positive job attitudes and personal well-being, no studies have yet examined the joint role of teacher happiness and emotional intelligence in key teacher job attitudes. The present study assesses (...) whether emotional intelligence interacts with levels of teacher happiness to jointly explain important teacher job attitudes. A total sample of 685 teaching professionals filled out a battery of scales including subjective happiness, emotional intelligence, job satisfaction, and turnover intention. Our results revealed that subjective happiness was significantly associated with both higher job satisfaction and lower turnover intention. Likewise, emotional intelligence was positively related to happiness and job satisfaction, and negatively related to turnover intention. Finally, interaction analysis showed the main effects of happiness and emotional intelligence in explaining teacher job attitudes. Beyond the main effects, the interaction effects of happiness and emotional intelligence were significant in predicting all teachers' job attitude indicators, even controlling for the effects of their sociodemographic variables. This work expands our knowledge about the role of teachers' positive emotions in the development of positive work attitudes, and also supports the inclusion of emotional skills in future teacher preparation programs as resources to facilitate work-related well-being. (shrink)

One of the main features of Heidegger’s thinking is his constant confrontation with the history of the western philosophy, above all with the greek and the modern. But the young Heidegger also maintained an important dialogue with medieval philosophy. This article is intended as an approximation to this last topic, in the light of the new volumes that appeared within the framework of the Gesamtausgabe. The heideggerian confrontation with medieval philosophy is primarly a philosophical confrontation and is changing according to (...) the changes in Heidegger’s own philosophical conceptions. On the other hand, the article does not deal with the problem of Heidegger’s relationship with the medieval Mystic. (shrink)

Empathy is a topic of continuous debate in the nursing literature. Many argue that empathy is indispensable to effective nursing practice. Yet others argue that nurses should rather rely on sympathy, compassion, or consolation. However, a more troubling disagreement underlies these debates: There’s no consensus on how to define empathy. This lack of consensus is the primary obstacle to a constructive debate over the role and import of empathy in nursing practice. The solution to this problem seems obvious: Nurses need (...) to reach a consensus on the meaning and definition of empathy. But this is easier said than done. Concept analyses, for instance, reveal a profound ambiguity and heterogeneity of the concept of empathy across the nursing literature. Since the term “empathy” is used to refer to a range of perceptual, cognitive, emotional, and behavioral phenomena, the presence of a conceptual ambiguity and heterogeneity is hardly surprising. Our proposal is simple. To move forward, we need to return to the basics. We should develop the concept from the ground up. That is, we should begin by identifying and describing the most fundamental form of empathic experience. Once we identify the most fundamental form of empathy, we will be able to distinguish among the more derivative experiences and behaviors that are addressed by the same name and, ideally, determine the place of these phenomena in the field of nursing. The aim of this article is, consequently, to lay the groundwork for a more coherent concept of empathy and thereby for a more fruitful debate over the role of empathy in nursing. In Part 1, we outline the history of the concept of empathy within nursing, explain why nurses are sometimes warry of adapting concepts from other disciplines, and argue that nurses should distinguish between adapting concepts from applied disciplines and from more theoretical disciplines. In Part 2, we show that the distinction between emotional and cognitive empathy—borrowed from theoretical psychology—has been a major factor in nurses’ negative attitudes toward emotional empathy. We argue, however, that both concepts fail to capture the most fundamental form of empathy. In Part 3, we draw on and present some of the seminal studies of empathy that can be found in the work of phenomenological philosophers including Max Scheler, Edmund Husserl, and Edith Stein. In Part 4, we outline how their understanding of empathy may facilitate current debates about empathy’s role in nursing. (shrink)

The aim of this paper is to provide an account of a certain variety of self-deception based on a model of self-knowledge. According to this model, one thinks that one has a belief on the basis of one’s grounds for that belief. If this model is correct, then our thoughts about which beliefs we have should be in accordance with our grounds for those beliefs. I suggest that the relevant variety of self deception is a failure of self-knowledge wherein the (...) subject violates this epistemic obligation. I argue that construing this type of self-deception as a failure of selfknowledge explains two important aspects of it: The tension that we observe between the subject’s speech and her actions, and our inclination to hold the subject responsible for her condition. I compare this proposal with two other approaches to self-deception in the literature; intentionalism and motivationalism. Intentionalism explains the two aspects of self-deception but it runs into the so called ‘paradoxes’ of self-deception. Motivationalism avoids those paradoxes but it cannot explain the two aspects of self-deception. (shrink)

This essay discusses four recent books on the Western, and one book on the classical Chinese, traditions of just war. It concentrates on the jus ad bellum moral criteria, giving attention to the centrality of the state in just war morality, to some challenges in reconceptualizing the jus ad bellum in the context of non-state agents, and to controversies over a “presumption against war.”.

Partimos de que en sociedades políticas complejas, aun siendo el Estado un artificio necesario para evitar situaciones de dominación, su entramado institucional no está exento de reproducir análogas situaciones a aquellas cuya eliminación justificaba su existencia. Analizaremos desde esta óptica las críticas de Rawls y Nozick al utilitarismo, al que acusan de amparar actuaciones injustas por parte del colectivo hacia los individuos. En concreto, abordaremos el problema de los derechos inviolables desde estas tres líneas de pensamiento para concluir que, a (...) pesar de que existen marcadas diferencias en sus respectivos planteamientos metodológicos, hay en las tres líneas de convergencia en lo sustantivo. Concluiremos con una réplica a las objeciones antiutilitaristas y una defensa, siguiendo a John Stuart Mill de la mayor adecuación de esta escuela a la hora de defender la inviolabilidad de ciertos derechos fundamentales. (shrink)

Es, quiza, la coleccion mas abierta que existe en cuestiones de etica, aunque se ha ocupado tambien de antropologia, estetica, ontologia, teoria del conocimiento e historia de la filosofia. El primer titulo que se publico en la coleccion fue la gran Historia de la filosofia y de la ciencia en tres volumenes de Ludovico Geymonat. A este le han seguido obras de A. J. Ayer, A. MacIntyre, Ernst Tugendhat, Antoni Domenech, Anna Estany, Agnes Heller, F. Fernandez Buey, Carlos Paris, (...) class='Hi'>Emilio Lledo, Manuel Sacristan, John Rawls o Ludwig Wittgenstein. Victoria Camps ha dirigido, ademas, una gran Historia de la etica, en tres volumenes, en la que han colaborado los mejores especialistas espanoles. Manual al dia y de lectura agil y amena sobre valores y conceptos como el de igualdad y prioridad, fundamentales en los estudios de la filosofia de hoy. (shrink)

Fernandez examines the lives and ideas of sociologists who shaped the main contours of the discipline. Weber, Marx, Durkheim, and Simmel fashioned the early ideas and approaches of sociology, and their ideas are still central to the discipline. Veblen, Mead, Goffman, and Berger added crucial conceptual approaches; they also serve to underscore the length and breadth of Sociology as a science.

In this article, I argue that phenomenological psychopathologists, despite their critical attitude toward mainstream psychiatry, still hold problematic prejudices about the nature of psychiatric conditions as illness or disorder. I suggest that phenomenological psychopathologists turn to resources in the neurodiversity and mad pride movements to critically reflect upon these prejudices and appreciate the methodological problems that they pose.

This book explores the significance of archery as ritual practice and literary metaphor in classical Confucian texts. Archery passages in the Analects, Mencius, and Xunzi are discussed in the light of Zhou culture and the troubled historical circumstances of early followers of the ruist master Confucius.

Según la liturgia, mi vida, es decir, la de cada cual, en su realidad concreta, no es «cosa» alguna, sino proyecto, empresa, misión; acontece, se va haciendo. La tradicional perspectiva cris-tiana reclama una intensificación del conocimiento, relativamente descuidado, de lo que significa ser persona. Un peso del pensamiento helénico, ajeno al cristianismo, ha orientado al pensamiento poste-rior, filosófico y también teológico, a un «sustancialismo» que ha lle-vado a reducir la persona a un tipo muy particular de «cosa».

Monitoring health is one of the basic principles of Occupational Health and Safety. The main objective of this monitoring will be the detection of possible damage to health arising from work. They try to discover the effects that the inherent risks with the work may cause the worker, which will show, given the case, through an alteration of health or the state of organic and functional state, both physically and mentally. Regarding the monitoring of health, there are many and varied (...) issues to be raised concerning the right to personal privacy. Thus, notably, whether there was effective consensus, and whether, in particular, the object and the purpose of the medical examination meant a disregard of the statutory scheme, an excess or even a failure to comply with the terms of the Spanish Constitution. The limits imposed by the law makers to the productive unit will play a key role in identifying the content of the company obligation to monitor health, being in many cases guarantees of constitutional rights. Therefore, the methods of health monitoring and control of workers will always be carried out respecting the privacy and dignity of the worker as well as the confidentiality of all information related to their health. (shrink)

The inner semiotic core of biology Content Type Journal Article Pages 1-3 DOI 10.1007/s11016-011-9547-z Authors Eliseo Fernández, Linda Hall Library of Science and Technology, Kansas City, MO 64110, USA Journal Metascience Online ISSN 1467-9981 Print ISSN 0815-0796.